Adipose Tissue Protects Against Skin Photodamage Through CD151- And AdipoQ- EVs
December 2024
in “
Cell Communication and Signaling
”
New to collagen? There is a guide in the encyclopedia. Read the guide → adipose tissue extracellular vesicles AT-EVs UVB exposure fibroblast proliferation collagen synthesis reactive oxygen species ROS DNA damage CD151 adiponectin AMPK NF-κB skin photoaging fat tissue EVs ultraviolet B collagen oxidative stress DNA repair AMP-activated protein kinase nuclear factor kappa-light-chain-enhancer of activated B cells skin aging
Studysummary This study found that subcutaneous adipose tissue-derived extracellular vesicles (AT-EVs) protect skin from photodamage by enhancing fibroblast proliferation and reducing oxidative stress compared to those from adipose-derived stem cells. Our plain-language summary of this paper — not a Tressless recommendation.
The study explores the protective role of adipose tissue-derived extracellular vesicles (AT-EVs) against skin photodamage, particularly from UVB exposure. Using nude mouse skin models, it was found that AT-EVs are more effective than those from adipose-derived stem cells (ADSC-EVs) in promoting fibroblast proliferation, enhancing collagen synthesis, and reducing reactive oxygen species (ROS) and DNA damage. This is attributed to the higher expression of CD151 and adiponectin in AT-EVs, which facilitate faster cellular uptake and activate protective pathways like AMPK while inhibiting NF-κB. These findings suggest that AT-EVs could be a promising therapeutic approach for skin photoaging and other related conditions.
