Adipose Tissue Protects Against Skin Photodamage Through CD151- And AdipoQ- EVs

    December 2024 in “ Cell Communication and Signaling ”
    Yanwen Wang, Poh‐Ching Tan, Qingfeng Li, Xuewen Xu, Shuang‐Bai Zhou
    TLDR Fat tissue vesicles protect skin from UV damage better than stem cell vesicles.
    The study explores the protective role of adipose tissue-derived extracellular vesicles (AT-EVs) against skin photodamage, particularly from UVB exposure. Using nude mouse skin models, it was found that AT-EVs are more effective than those from adipose-derived stem cells (ADSC-EVs) in promoting fibroblast proliferation, enhancing collagen synthesis, and reducing reactive oxygen species (ROS) and DNA damage. This is attributed to the higher expression of CD151 and adiponectin in AT-EVs, which facilitate faster cellular uptake and activate protective pathways like AMPK while inhibiting NF-κB. These findings suggest that AT-EVs could be a promising therapeutic approach for skin photoaging and other related conditions.
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