Exosomes as Emerging Therapeutics in Aesthetic and Regenerative Medicine: A Scoping Review

February 2026 in “ Journal of Regenerative Medicine and Biology Research ”

Nassar El Asaad, Rawad Salameh, Sarah Alshamsi, Nour Bou Atme, Maria Nassif, Karl Abou Mrad, Charbel Khalil

exosomes extracellular vesicles anti-aging regenerative medicine intercellular communication biomolecules inflammation tissue regeneration cellular waste removal stem cell-based regenerative medicine anti-inflammatory treatments senescence-associated pathways cosmetology

Studysummary This study explores the potential roles of exosomes in anti-aging applications, highlighting their ability to modulate inflammation, promote tissue regeneration, and transfer bioactive molecules to rejuvenate aging tissues and reverse cellular dysfunction. Our plain-language summary of this paper — not a Tressless recommendation.

Exosomes, small extracellular vesicles, are gaining attention for their potential in anti-aging and regenerative medicine due to their role in intercellular communication and as carriers of biomolecules. They modulate inflammation, promote tissue regeneration, and facilitate cellular waste removal, which are crucial for aging and longevity. Exosomes can transfer bioactive molecules to rejuvenate aging tissues and reverse cellular dysfunction. Recent advancements highlight their use in stem cell-based regenerative medicine, anti-inflammatory treatments, and modulation of senescence-associated pathways, making them promising candidates in cosmetology for anti-aging effects.

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Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment

research Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment

July 2024 in “Pharmaceutics”

In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.

research Exosomal MicroRNA-Based Therapies for Skin Diseases

December 2023 in “Regenerative therapy”

In this review, the authors reported that exosomal miRNA-based therapies showed promising therapeutic effects on nine skin diseases in animal models, with enhanced outcomes observed when using miRNA-overexpressing exosomes compared to natural ones; however, no comparisons to standard treatments were available.

research Hair Restoration Techniques

July 2023 in “Facial Plastic Surgery”

This review provides an overview of current hair restoration techniques used in facial plastic surgery, including medications, injections like platelet-rich plasma, light therapy, and follicular unit extraction. Results are not reported.

Innovations in Skin and Soft Tissue Aging: A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes

research Innovations in Skin and Soft Tissue Aging: A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes

17 citations , May 2023 in “Aesthetic Plastic Surgery”

This review found that among emerging technologies for skin anti-aging, stem cell therapies using recipient chimerism might be more beneficial than CRISPR-Cas9 and other current innovations, though further studies on safety and efficacy are needed.

research The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics

47 citations , February 2021 in “Pharmacological research”

This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.

research Alopecia and Techniques in Hair Restoration: An Overview for the Cosmetic Surgeon

5 citations , February 2019 in “Oral and Maxillofacial Surgery”

Hair loss can be reversed or even cured using advanced hair restoration techniques, with rare complications like swelling and bleeding.

research Advances in Hair Restoration

17 citations , November 2017 in “Dermatologic Clinics”

This article discusses advancements in hair restoration, highlighting the use of robotics and follicular unit extraction along with adjuvant therapies like platelet-rich plasma, but presents no new clinical findings.

research Normal and Aging Hair Biology and Structure: Aging and Hair

20 citations , January 2015 in “Current problems in dermatology”

This article discusses the aging-related changes in hair structure and function, and examines various treatments like light therapy, minoxidil, and finasteride aimed at mitigating hair thinning and loss, but reports no new clinical results.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.