Exosomes in Trichology: A Literature Review

This case study highlights rose stem cell-derived exosomes combined with thulium laser therapy as a promising treatment for stress-induced alopecia areata, achieving significant hair regrowth and pigmentation without corticosteroid side effects, though further research is needed for broader application.

This study found that exosomes derived from human umbilical cord mesenchymal stem cells effectively promoted growth in human hair dermal papilla cells, implicating the PI3K and Akt pathways as potential targets for treating hair loss.

This study found that PRP-Exos may stimulate hair follicle growth and enhance regeneration in cases of AGA by activating the Wnt/β-Catenin signaling pathway, showing potential both in vitro and in vivo.

This study found that an exosome formulation with plant extracts significantly increased hair regrowth in men with male pattern alopecia compared to a placebo, without notable adverse effects.

This study found that human adipose-derived MSC exosomes (hADSC-Exos) may enhance dermal papillary cell proliferation and migration by activating the Wnt/β-catenin signaling pathway, potentially reversing the effects of dihydrotestosterone in androgenetic alopecia.

This research found that exosome-derived long non-coding RNA AC010789.1, modified by FTO and hnRNPA2B1, enhanced human hair follicle stem cell proliferation against androgenic alopecia through the activation of S100A8/Wnt/β-catenin signaling pathways.

In this case series, mesenchymal stem cell exosomes were reported to improve hair length, density, pigmentation, and cuticle layer recovery in three patients with acquired trichorrhexis nodosa, suggesting potential as a therapeutic approach for this hair condition.

This study found that umbilical cord mesenchymal stem cell-derived exosomes improved hair growth in mice with androgenetic alopecia by promoting hair follicle stem cell stemness through the RAS/ERK pathway, suggesting a potential new treatment strategy for this condition.

In this review, researchers found that while exosomes show potential for treating hair loss with rare side effects reported among 125 patients, larger clinical trials with consistent manufacturing standards and regulatory oversight are needed to confirm efficacy and ensure safety.

This study found that treating patients with androgenetic alopecia using exosomes from adipose tissue stem cells over 24 weeks significantly increased hair density and patient satisfaction without severe adverse effects, suggesting a promising alternative treatment for hair loss.

This study highlights examples of successful hair growth using combined laser therapy and autologous exosome therapy, suggesting a synergistic effect that may enhance beauty treatments and other therapeutic applications.

This review summarizes recent advancements in using exosomes for promoting hair growth, finding that exosomes from various cells, like dermal papilla and mesenchymal stem cells, show promise as a potential new treatment route for alopecia.

This review highlights the potential of exosomes as a novel therapeutic approach for skin diseases and aging, due to their stability, transportability, and ability to carry various bioactive compounds to target cells.

This abstract introduces "Dermis," an open-access, peer-reviewed journal focused on dermatology, which publishes significant new research in the field of dermatology. Specific research results are not included here.

This review highlights the potential of exosomes, particularly their microRNA components, as promising candidates for developing effective hair loss treatments by exploring their roles in hair follicle development and regeneration.

In this study, researchers found that exosomes derived from dermal sheath cup cells (Exo DSCCs) improved proliferation, viability, and migration while reducing apoptosis in senescent dermal papilla cells, also enhancing hair follicle reconstruction and suggesting a potential strategy for combating senile alopecia.

This study investigated the effects of exosomes from human umbilical cord mesenchymal stem cells on hair loss in mice with alopecia areata, emphasizing the potential of these easily isolated and stored exosomes for research and clinical treatment.

This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.

This study found that while clinical evidence is limited, early preclinical results suggest exosome treatment may enhance hair growth and warrant further research for therapeutic use in alopecia.

This study reports that mesenchymal stromal cell-derived extracellular vesicle injections led to complete hair regrowth in a patient with persistent chemotherapy-induced alopecia.

This review discusses the potential of exosomes as a therapy for hair loss and the need for better regulation and understanding of their molecular effects, but reports no new clinical results.

This study found that exosomes from adipose mesenchymal stromal cells, particularly those carrying miR-122-5p, may enhance hair follicle regeneration in androgenic alopecia by targeting the TGF-β/SMAD3 axis.

This review discusses the potential role of exosomes in aesthetic medicine for skin rejuvenation and hair restoration, but reports no new clinical findings and emphasizes the need for further studies with regulatory oversight.

In this study, the authors reported that oral dutasteride at 0.5 mg/day showed a probable greater efficacy in treating male androgenetic alopecia compared to finasteride and minoxidil, but it may cause sexual dysfunction and neuropsychiatric side effects.

This review found that while preclinical studies highlight the potential benefits of exosome therapeutics for hair loss, clinical evidence on their safety and effectiveness for alopecia is currently lacking, requiring further research.

This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.

This abstract provides information about data availability and author affiliations but does not contain results or conclusions from the study itself.

This study found that photobiomodulation enhanced hair regeneration in injured dermis of mice, likely through increased migration and exosome secretion of dermal papilla cells via the Akt/GSK-3β/β-catenin pathway.

This study found that adipose-derived stem cell exosomes promoted hair follicle regeneration in mice, resulting in a higher number of regenerated hairs and follicles compared to the control group.

In this study, fisetin applied to the dorsal skin of mice activated hair follicle stem cells through exosome secretion from keratinocytes, promoting hair growth.

This review explains the evolution and current techniques of follicular unit transplantation for hair restoration, identifying conditions suitable for surgery and offering guidelines for dermatologists to assess candidate suitability, focusing on male and female pattern hair loss.

Exosomes from stem cells might help treat hair loss.

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

In this study, dermal papilla cell-derived exosomes accelerated hair follicle growth in mice, suggesting potential for treating hair loss by modulating key signaling pathways.

This review discusses current knowledge and management strategies for chemotherapy-induced alopecia, highlighting the need for better research prioritization and providing patient support materials, but reports no new clinical results.

This review discusses the limited objective evidence for using finasteride in women with alopecia, suggesting that it could be considered for those who don't benefit from minoxidil, but reports no new clinical results.

This article discusses treatment options for androgenetic alopecia, noting that medical interventions like finasteride and minoxidil can halt and partially reverse hair loss in mild to moderate cases, especially when combined with surgery.

Minoxidil promotes hair growth in male pattern baldness.