Clinical Advances in Exosome-Based Therapies for Aesthetic Medicine: A Systematic Review and Meta-Analysis of Human Clinical Trials

    September 2025 in “ Aesthetic Surgery Journal ”
    Emily R Stack, Colby Spongberg, Savannah C. Braud … Michelle Elway
    Studysummary In this systematic review and meta-analysis, researchers found that exosome therapies significantly improved facial wrinkles by 20.2% and enhanced hair density and thickness by 23.6% and 18%, respectively, despite challenges in generalizability due to study heterogeneity and nonstandardized protocols.
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    Research cited in this study 9

    1. A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia Life · 2025
    2. Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study Aesthetic Plastic Surgery · 2024
    3. Exploring the Efficacy and Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Androgenic Alopecia 2024
    4. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    5. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    6. Fibroblast-Derived Growth Factors and Exosomes as Cosmeceuticals Dermatological reviews · 2023
    7. Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients Journal of cosmetic dermatology · 2022
    8. The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics Pharmacological research · 2021
    9. Exosome for Hair Regeneration: From Bench to Bedside Journal of the American Academy of Dermatology · 2019