Fibroblast-Derived Growth Factors and Exosomes as Cosmeceuticals

    October 2023 in “ Dermatological reviews ”
    Rahul Mehta, Kuniko Kadoya, Prithwiraj Maitra, Lisa Goberdhan, Elizabeth T Makino, Gail K. Naughton, Mitchel P. Goldman
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    TLDR Fibroblast-derived growth factors and exosomes can significantly improve skin aging.
    The document explores the efficacy of fibroblast (FB)-derived growth factors and exosomes in skin rejuvenation, noting their significant role in improving skin quality parameters such as photodamage, facial laxity, texture, and radiance. Clinical studies, including a pilot study with 10 patients using FB exosomes for 12 weeks, showed statistically significant improvements in skin quality. The biological activity of FB secretome varies with culture conditions, with hypoxic conditions enhancing anti-inflammatory activities. The study underscores the need for further research to optimize formulations and ensure the long-term stability of these exosome-containing products. The research was supported by Allergan Aesthetics, and ethical consent for publication was obtained.
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