Fibroblast-Derived Growth Factors and Exosomes as Cosmeceuticals
October 2023
in “
Dermatological reviews
”
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Studysummary In this study, exosomes isolated from fibroblast secretome and applied to the skin improved aging parameters like wrinkles and sagging over 12 weeks, suggesting these exosomes may enhance skincare formulations if their biological activity remains stable.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document explores the efficacy of fibroblast (FB)-derived growth factors and exosomes in skin rejuvenation, noting their significant role in improving skin quality parameters such as photodamage, facial laxity, texture, and radiance. Clinical studies, including a pilot study with 10 patients using FB exosomes for 12 weeks, showed statistically significant improvements in skin quality. The biological activity of FB secretome varies with culture conditions, with hypoxic conditions enhancing anti-inflammatory activities. The study underscores the need for further research to optimize formulations and ensure the long-term stability of these exosome-containing products. The research was supported by Allergan Aesthetics, and ethical consent for publication was obtained.
