TLDR Fibroblast-derived growth factors and exosomes can significantly improve skin aging.
The document explores the efficacy of fibroblast (FB)-derived growth factors and exosomes in skin rejuvenation, noting their significant role in improving skin quality parameters such as photodamage, facial laxity, texture, and radiance. Clinical studies, including a pilot study with 10 patients using FB exosomes for 12 weeks, showed statistically significant improvements in skin quality. The biological activity of FB secretome varies with culture conditions, with hypoxic conditions enhancing anti-inflammatory activities. The study underscores the need for further research to optimize formulations and ensure the long-term stability of these exosome-containing products. The research was supported by Allergan Aesthetics, and ethical consent for publication was obtained.
3 citations,
January 2023 in “Regenerative Medicine” Exosomes show promise for skin and hair rejuvenation, but more research and regulation are needed before they can be widely used.
488 citations,
July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
3 citations,
September 2023 in “Skin research and technology” New treatments for skin damage from UV light using stem cells and their secretions show promise for skin repair without major risks.
47 citations,
February 2021 in “Pharmacological research” Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.
3 citations,
February 2023 in “International Journal of Molecular Sciences” Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.
8 citations,
June 2022 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.
Tiny particles called extracellular vesicles show potential for improving skin health in cosmetics, but more research is needed to confirm their safety and effectiveness.
