Skin Stem Cells, Their Niche, and Tissue Engineering Approach for Skin Regeneration

    January 2019 in “ Advances in experimental medicine and biology ”
    Nur Kübra Çankirili, Özlem Altundag, Betül Çelebi‐Saltik
    TLDR Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.
    The document reviewed the role of skin stem cells and their niche in skin regeneration, emphasizing the potential of tissue engineering approaches. It highlighted the importance of signaling pathways like Wnt, BMP, Hedgehog, and Notch in regulating stem cell behavior and hair follicle development. Various studies on the use of adipose-derived, hair follicle, and mesenchymal stem cells for wound healing and tissue repair were discussed. The review also covered the use of autologous keratinocytes and pericytes in treating nonhealing wounds and skin regeneration. Overall, it underscored significant advancements and future potential in stem cell-based skin regeneration.
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