Skin Stem Cells, Their Niche, and Tissue Engineering Approach for Skin Regeneration

January 2019 in “ Advances in experimental medicine and biology ”

Nur Kübra Çankirili, Özlem Altundag, Betül Çelebi‐Saltik

skin stem cells epidermal stem cells tissue engineering skin regeneration wound repair stem cell-based skin substitutes acute wounds chronic wounds dermatological research pharmacological research

TLDR Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.

The document reviewed the role of skin stem cells and their niche in skin regeneration, emphasizing the potential of tissue engineering approaches. It highlighted the importance of signaling pathways like Wnt, BMP, Hedgehog, and Notch in regulating stem cell behavior and hair follicle development. Various studies on the use of adipose-derived, hair follicle, and mesenchymal stem cells for wound healing and tissue repair were discussed. The review also covered the use of autologous keratinocytes and pericytes in treating nonhealing wounds and skin regeneration. Overall, it underscored significant advancements and future potential in stem cell-based skin regeneration.

View this study on link.springer.com →

Discuss this study in the Community →

Cited in this study

15 / 15 results

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations , March 2018 in “International Journal of Molecular Sciences”

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

38 citations , June 2017 in “The Journal of Dermatology”

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

Stem cells are crucial for skin repair and new treatments for chronic wounds.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

96 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Stem Cell Dynamics in the Hair Follicle Niche

135 citations , January 2014 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research Epidermal Stem Cells: An Update on Their Potential in Regenerative Medicine

9 citations , March 2013 in “Expert opinion on biological therapy”

Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.

research Epidermal Stem Cells: Practical Perspectives and Potential Uses

62 citations , August 2009 in “British Journal of Dermatology”

Epidermal stem cells could lead to new treatments for skin and hair disorders.

research Human Skin Stem Cells and the Aging Process

143 citations , November 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , October 2005 in “Journal of Investigative Dermatology”

Applying a special compound can promote hair growth without harmful side effects.

research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

194 citations , May 2000 in “Journal of Investigative Dermatology”

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

research Mouse notch: expression in hair follicles correlates with cell fate determination.

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

Mouse Notch is important for determining cell roles in hair follicles.

research The secret life of the hair follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.