Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis

September 2024 in “ Journal of Inflammation Research ”

Minghui Wang, Zhi‐Wei Lai, Silu Lv, W. Yang, Fengping Zheng, Di-Hua He, Xiaofang Liu, Rong Zhong, Mulan Qahar, Guang Yang

We don't know much about this study yet.

We're maintaining the world's largest resposity of hair loss research. You can help out the community by sending a PDF of this study here . Not sure how to get a study's PDF? You can email the authors of the study.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

7 citations, February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

research Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

6 citations, April 2022 in “Journal of diabetes research”

Type 2 diabetes slows down skin and hair renewal by blocking important stem cell activation in mice.

research Hair Transplantation: Basic Overview

30 citations, April 2021 in “Journal of The American Academy of Dermatology”

Hair transplantation can effectively restore hair in balding areas.

research Glucose Metabolism Regulates Expression of Hair-Inductive Genes of Dermal Papilla Spheres via Histone Acetylation

6 citations, March 2020 in “Scientific reports”

Hair growth genes work better with more glucose due to changes in gene-regulating markers.

research Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation

202 citations, August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss

56 citations, May 2017 in “Nature Cell Biology”

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations, March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine

30 citations, March 2017 in “ACS biomaterials science & engineering”

Hair follicles are valuable for regenerative medicine and wound healing.

research Follicular Unit Extraction: Minimally Invasive Surgery for Hair Transplantation

153 citations, August 2002 in “Dermatologic Surgery”

Follicular Unit Extraction (FUE) is a less invasive hair transplant method with minimal scarring, suitable for about 60% of patients, especially those needing fewer grafts and quicker recovery.

Related Research

1 / 1 results

research Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model

17 citations, December 2010 in “Journal of Investigative Dermatology”

Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.