Activation of Astrocytes In Vitro by Macrophages Polarized with Keratin Biomaterial Treatment

January 2016 in “ Open journal of regenerative medicine ”

Bailey V. Fearing, Mark Van Dyke

keratin biomaterial macrophage polarization M2 phenotype astrocyte reactivity CSPG production glial scar spinal cord injury keratin M2 macrophages chondroitin sulfate proteoglycans SCI

Studysummary This study found that macrophages treated with keratin in vitro were more similar to anti-inflammatory M2 macrophages and reduced astrocyte reactivity, potentially limiting secondary inflammatory damage after spinal cord injury.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on scirp.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Treatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repair

7 citations , March 2014 in “ISRN Biomaterials”

In this study, a keratin hydrogel improved survival rates and functional recovery in rats with spinal cord injuries, suggesting potential for SCI treatment that merits further investigation.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , October 2007 in “Biomaterials”

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.