TLDR Activating TLR3 may help produce retinoic acid, important for tissue regeneration.
The document presents a hypothesis that in the process of wound-induced hair neogenesis (WIHN), where adult mice regenerate hair follicles after a large wound, the activation of toll-like receptor 3 (TLR3) by double-stranded RNA (dsRNA) plays a crucial role. The authors suggest that TLR3 activation may stimulate the synthesis and signaling of retinoic acid, which is essential for tissue regeneration. This hypothesis draws a parallel between the natural regenerative processes observed in mice and common clinical facial rejuvenation methods in humans, such as laser treatments or dermabrasion, as well as the application of topical retinoids, implying that these treatments may operate through a similar biological pathway involving TLR3 and retinoic acid.
27 citations,
April 2017 in “Journal of Investigative Dermatology” After skin is damaged, noncoding dsRNA helps prostaglandins and Wnts work together to repair tissue and promote hair growth.
128 citations,
August 2015 in “Cell Stem Cell” Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
31 citations,
September 2012 in “Journal of biological chemistry/The Journal of biological chemistry” The right amount of retinoic acid is essential for normal hair growth and development.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Double stranded RNA helps skin wounds heal by coordinating specific proteins and signaling pathways.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Astrotactin2 affects hair follicle orientation and skin cell polarity.
28 citations,
October 2019 in “Seminars in Cell & Developmental Biology” Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.
10 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
4 citations,
October 2021 in “Journal of Cellular and Molecular Medicine” White blood cells and their traps can slow down the process of new hair growth after a wound.
