Hypothesis: Wound-Induced TLR3 Activation Stimulates Endogenous Retinoic Acid Synthesis and Signalling During Regeneration

The document presents a hypothesis that in the process of wound-induced hair neogenesis (WIHN), where adult mice regenerate hair follicles after a large wound, the activation of toll-like receptor 3 (TLR3) by double-stranded RNA (dsRNA) plays a crucial role. The authors suggest that TLR3 activation may stimulate the synthesis and signaling of retinoic acid, which is essential for tissue regeneration. This hypothesis draws a parallel between the natural regenerative processes observed in mice and common clinical facial rejuvenation methods in humans, such as laser treatments or dermabrasion, as well as the application of topical retinoids, implying that these treatments may operate through a similar biological pathway involving TLR3 and retinoic acid.