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    Glossary RNA-induced silencing complex

    molecular machine that regulates gene expression by degrading mRNA

    The RNA-induced silencing complex (RISC) is a molecular machine within cells that plays a crucial role in gene regulation. It uses small RNA molecules, such as microRNAs (miRNAs) or small interfering RNAs (siRNAs), to identify and bind to specific messenger RNA (mRNA) sequences, leading to the degradation of the mRNA or the inhibition of its translation into proteins. This process is essential for controlling gene expression and maintaining cellular function.

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    1. Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein 2023
    2. The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis Molecular therapy. Nucleic acids · 2022 · 19 citations
    3. Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies Frontiers in Pharmacology · 2026
    4. Keratin disorders: from gene to therapy 2011 · 109 citations
    5. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
    6. From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Molecular and Cellular Endocrinology · 2017 · 17 citations
    7. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014 · 53 citations
    8. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015 · 6 citations
    9. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells Revista Da Associacao Medica Brasileira · 2017 · 2 citations
    10. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    11. Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation PLoS ONE · 2025
    12. The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs) Proteomes · 2023 · 4 citations
    13. Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath 2019 · 12 citations
    14. Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges BioEssays · 2014 · 106 citations
    15. Spatiotemporal dynamics of mammalian wound healing Cell Discovery · 2026 · 4 citations
    16. TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target Medeniyet Medical Journal · 2025 · 4 citations
    17. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration Journal of Investigative Dermatology · 2017 · 27 citations
    18. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    19. miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network Frontiers in Cell and Developmental Biology · 2022
    20. Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States Frontiers in Immunology · 2021 · 50 citations
    21. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    22. Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo International Journal of Molecular Sciences · 2026
    23. Stimuli-responsive hydrogels for radiation-induced skin injury: from passive barriers to autonomous drug delivery systems Regenerative Biomaterials · 2026
    24. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin Nature Immunology · 2012 · 286 citations
    25. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells Stem Cells and Development · 2011 · 67 citations
    26. Downregulation of Sonic hedgehog signaling induces G2‐arrest in genital warts Skin Research and Technology · 2022 · 4 citations
    27. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020 · 12 citations
    28. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    29. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    30. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations