Loss Of Dicer In Newborn Melanocytes Leads To Premature Hair Graying And Changes In Integrin Expression

    September 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Juliette Bertrand, Valérie Petit, Zackie Aktary … Lionel Larue
    Studysummary This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.
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    Research cited in this study 8

    1. Targeted Knockout of Beta-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects Journal of Investigative Dermatology · 2020
    2. Any Route for Melanoblasts to Colonize the Skin Experimental Dermatology · 2016
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    4. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    5. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    6. Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    7. Changes in Fibronectin, Laminin, and Type IV Collagen Distribution Relate to Basement Membrane Restructuring During the Rat Vibrissa Follicle Hair Growth Cycle PubMed · 1992
    8. Expression of Basement Membrane Components Through Morphological Changes in the Hair Growth Cycle Developmental Biology · 1985