Loss Of Dicer In Newborn Melanocytes Leads To Premature Hair Graying And Changes In Integrin Expression

    Juliette Bertrand, Valérie Petit, Zackie Aktary, Pierre de la Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue
    Image of study
    TLDR Removing Dicer from pigment cells in newborn mice causes early hair graying and changes in cell migration molecules.
    The study demonstrates that the loss of the enzyme Dicer in newborn melanocytes leads to premature hair graying due to misplacement and depletion of melanocyte stem cells (McSCs). Using mouse models and cell lines, researchers found that Dicer inactivation disrupts melanin transfer, causing hair to lose color. The study identifies the miR-92b–ItgaV pathway as crucial, with miR-92b regulating ItgaV levels and affecting melanocyte migration. Dicer knockdown altered the expression of 280 genes related to cell adhesion and migration, particularly integrins. These findings highlight Dicer's essential role in maintaining McSCs and proper melanocyte migration, linking stress to premature hair graying.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 88 results

      community Where to find Botox online

      in Treatment  6 upvotes 4 years ago
      The user is looking for a place to buy genuine Botox online for scalp use. They are seeking recommendations for reliable sources.

      community Going for mixology with fingers crossed.

      in Treatment 1 week ago
      The user is experimenting with a mix of topical treatments, including finasteride and minoxidil, to improve hair growth, particularly at the temples and core. They are also trying various oils, despite skepticism about their effectiveness, to see if they can enhance results without causing harm.

      community Two months of minoxidil 5mg only!

      in Progress Pictures  197 upvotes 1 week ago
      The conversation discusses hair loss treatments, specifically the use of minoxidil and the potential addition of finasteride. The user has seen some progress with minoxidil but is hesitant about finasteride due to possible side effects, while others suggest combining both for better long-term results.

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  26 upvotes 1 year ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community DUT Risk profile for having kids?

      in Finasteride/Dutasteride  5 upvotes 2 years ago
      The user has been using a hair loss treatment including oral Minoxidil, topical Minoxidil with Tretinoin and Finasteride, and is considering adding Dutasteride but is concerned about the potential side effects and risks regarding fertility. A reply suggests that having children while on these medications should be fine, advising to avoid letting the partner come into contact with the drugs.

      community Forgot min+fin whilst travelling

      in General  82 upvotes 2 weeks ago
      The user forgot their minoxidil and finasteride while traveling in Indonesia and is concerned about hair loss. They are advised that a 6-week break might cause some shedding but not drastic changes, and it's safer to wait for friends to bring the medication due to strict drug laws.

    Similar Research

    5 / 890 results