Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development

May 2020 in “ Frontiers in cell and developmental biology ”

Neda Vishlaghi, Thomas S. Lisse

Dicer bulge stem cells microRNAs anagen phase hair follicle development Tarbp2 microRNA biogenesis alopecia hair growth hair loss hair follicle stem cells

Studysummary In this study, researchers found that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in post-natal mice.

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The study investigated the role of Dicer and bulge stem cell-dependent microRNAs in hair follicle development during the anagen phase. It found that Dicer, essential for microRNA processing, was crucial for the proper function and maintenance of hair follicle stem cells, with its absence leading to impaired hair growth and follicle development. Tarbp2 was not essential for anagen development. The research highlighted the importance of Dicer-dependent microRNA biogenesis in post-natal hair follicle growth and suggested that targeting microRNA pathways could be a potential therapeutic strategy for hair loss conditions. The study provided insights into the molecular mechanisms governing hair growth and the potential for developing new treatments for alopecia.

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