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    Glossary Small Interfering RNA

    molecule that silences specific genes by degrading their mRNA

    Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

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    1. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    2. The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis Frontiers in cell and developmental biology · 2022 · 3 citations
    3. Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6 Journal of Biological Chemistry · 2009 · 253 citations
    4. Keratin disorders: from gene to therapy 2011 · 109 citations
    5. Advances in transdermal siRNAs delivery: A review of current research progress Non-coding RNA Research · 2023 · 20 citations
    6. Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells Journal of Dermatological Science · 2011 · 19 citations
    7. OVO Homolog-Like 1, a Target Gene of the Wnt/β-Catenin Pathway, Controls Hair Follicle Neogenesis Journal of Investigative Dermatology · 2013 · 9 citations
    8. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015 · 6 citations
    9. Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes Frontiers in Cell and Developmental Biology · 2020 · 5 citations
    10. Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells Journal of Dermatological Science · 2012 · 2 citations
    11. DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation Biochemical and Biophysical Research Communications · 2023 · 1 citations
    12. 854 CCL5 affects the hair-inductive capacity of three-dimensional (3D)-cultured dermal papilla cells Journal of Investigative Dermatology · 2017 · 1 citations
    13. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    14. ISID1343 - Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia 2023
    15. 1324 Impairment of hair-inducing capacity of 3D-cultured human dermal papilla cells by the ablation of STAT5 Journal of Investigative Dermatology · 2018
    16. 478 Mutation-specific siRNA Knockdown of GJB2 − Potential gene therapy for Keratitis-ichthyosis-deafness Syndrome Journal of Investigative Dermatology · 2017
    17. 705 Ablation of alkaline phosphatase in human dermal papilla spheroid impairs hair follicle induction Journal of Investigative Dermatology · 2016
    18. Updates in Treatment for Androgenetic Alopecia Annals of Dermatology · 2025
    19. Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy OPAL (Open@LaTrobe) (La Trobe University) · 2025
    20. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    21. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    22. 1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia Journal of Investigative Dermatology · 2023
    23. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    24. Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells <i>in vitro</i> Medical academic journal · 2025
    25. Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy International Journal of Molecular Sciences · 2024 · 1 citations
    26. Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing Frontiers in Immunology · 2024 · 7 citations
    27. Hair Coloration by Gene Regulation: Fact or Fiction? Trends in biotechnology · 2015 · 15 citations
    28. Understanding the Role of Type I Interferons in Cutaneous Lupus and Dermatomyositis: Toward Better Therapeutics Arthritis & Rheumatology · 2024 · 14 citations
    29. Anticytokine therapy, particularly anti-IFN-γ, in Th1-mediated autoimmune diseases Expert Review of Clinical Immunology · 2005 · 9 citations
    30. Effects of mesenchymal stem cell therapy on alopecia areata in cellular and hair follicle organ culture models Experimental Dermatology · 2018 · 16 citations