TLDR Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.
The document from December 2018 explored the use of modified Keratinocyte Growth Factor (KGF) messenger RNA (mRNA) to stimulate keratinocyte proliferation and migration, which are essential for wound healing. The in vitro study showed that transfection with KGF-mRNA led to increased KGF protein release and improved reepithelialization in scratch assays, suggesting that mRNA therapy could be a promising approach for enhancing wound healing. The study highlighted the benefits of mRNA therapy, such as its temporary effect and avoidance of risks associated with gene therapy. While the study demonstrated positive results in cell cultures, it did not involve human subjects and did not specify the number of cells used. The authors recommended further research to validate the use of KGF-mRNA in wound therapy.
23 citations,
January 2014 in “Molecular Therapy” Applying a special DNA plasmid to the skin can make it thicker and stronger.
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113 citations,
December 2000 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” KGF and activin are crucial for skin healing and repair.
20 citations,
February 2018 in “Cell transplantation” Cinnamomum osmophloeum leaf extract may help treat hair loss by promoting hair growth and increasing hair cell proliferation.
[object Object] 36 citations,
August 2022 in “Molecular Therapy — Nucleic Acids” Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.
22 citations,
December 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology” Baicalin helps hair grow by boosting certain cell activities and speeding up hair cycle in mice.
5 citations,
January 2017 in “Dermatologic Surgery” Storing hair follicle micrografts for longer times can cause them to enter a state similar to the natural hair shedding phase, which might impact hair transplant results.
25 citations,
December 2021 in “Stem Cell Research & Therapy” MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.
