Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

    January 2014 in “ Molecular Therapy ”
    Chunqing Dou, Frank Lay, Amir Ansari, Donald J Rees, Ali Ahmed, Olga Kovbasnjuk, Aerielle E. Matsangos, Jiajun Du, Sayed Mohammad Hosseini, Charles Steenbergen, Karen Fox-Talbot, Aaron Tabor, James A. Williams, Lixin Liu, Guy Marti, John W. Harmon
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    Studysummary This study found that topically delivering KGF-1 DNA plasmid increased epithelial thickness and skin strength, suggesting potential benefits for strengthening compromised skin. Our plain-language summary of this paper — not a Tressless recommendation.
    In the 2014 study, researchers explored a new method to strengthen skin by topically applying a DNA plasmid that delivers keratinocyte growth factor-1 (KGF-1). The study, likely conducted on animal models, demonstrated that the KGF-1 DNA plasmid increased KGF-1 mRNA and protein production, resulting in a significant increase in epithelial thickness (26±2 µm compared to 16±4 µm in the control group) and a tendency for increased dermal thickness (255±36 µm compared to 162±16 µm in the control group). Biomechanical tests showed that the KGF-1-treated skin was stronger than the control. These findings suggest that the topical delivery of KGF-1 DNA plasmid could be a potential treatment to enhance the durability of compromised skin. The number of participants or subjects was not specified in the summary.
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