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Growth Factors IGF-1 and KGF and Adipose-Derived Stem Cells Promote Migration and Viability of Primary Human Keratinocytes in an In Vitro Wound Model

research Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model

8 citations , February 2025 in “Frontiers in Medicine”

This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.

research Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

23 citations , January 2014 in “Molecular Therapy”

This study found that topically delivering KGF-1 DNA plasmid increased epithelial thickness and skin strength, suggesting potential benefits for strengthening compromised skin.

research Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli

5 citations , May 2023 in “Microbial Cell Factories”

This study found that a newly produced version of KGF-1 with 135 residues maintained biological activity and could serve as an alternative to the standard 140-residue KGF-1.

research Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine

4 citations , January 2017 in “Annals of Dermatology”

Tianeptine may help prevent hair loss by promoting hair growth and reducing cell death.

research Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli

2 citations , May 2022 in “Research Square (Research Square)”

This study demonstrates that the amino-terminally shortened KGF-1 variant with 135 residues maintains biological activity, suggesting it may serve as an alternative to the original KGF-1 for certain therapeutic applications.

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community Experiment with Growth Factors and Microneedling

4 upvotes 11 months ago

The conversation is about experimenting with microneedling and growth factor topicals for hair growth, avoiding Minoxidil due to shedding concerns. The treatment includes microneedling, growth factor topicals, finasteride, biotin, and a caffeine shampoo.

community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Wtf have we been doing for the last 30 years

in Treatment 548 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Subcutaneous Scalp fat and Hair loss? Interested in others annecdotal experience or knowledge.

6 upvotes 3 years ago

Subcutaneous scalp fat may be linked to hair loss, with theories suggesting that fat loss can lead to reduced blood flow and increased DHT activity, contributing to hair loss. Treatments discussed include PRP/PRF injections and fat transfer to improve scalp thickness and blood flow.

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Stem Cell Factor

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