Ablation of Alkaline Phosphatase in Human Dermal Papilla Spheroid Impairs Hair Follicle Induction

April 2016 in “ Journal of Investigative Dermatology ”

Mi Hee Kwack, M. Kim, J. Kim, Young Kwan Sung

alkaline phosphatase hair follicle neogenesis dermal papilla cells small interfering RNA trichogenicity ALP DP cells siRNA

TLDR Removing alkaline phosphatase from human skin cells hinders the creation of new hair follicles.

Seven years ago, a study conducted by M. Kwack at Kyungpook National University in Korea demonstrated that alkaline phosphatase (ALP) plays a critical role in hair follicle neogenesis. The study showed that sphere formation increased the ability of cultured human dermal papilla (DP) cells to induce hair follicles from mouse epidermal cells. ALP activity, which was found to be correlated with the hair-inducing capacity of murine DP cells, was significantly restored in human DP spheres. However, when ALP was knocked down using small interfering RNA (siRNA), a significant impairment in hair follicle induction was observed. This suggests that ALP is crucial for the maintenance of trichogenicity, or the ability to generate hair.

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