Prevention of H2O2-Induced Cellular Senescence in Human Hair Follicle Dermal Papilla Cells

April 2017 in “ Journal of Investigative Dermatology ”

Alison D. Pawlus, Anke Van Summeren, L. Declercq, T. Mammone, Gregory A. Hawkins

cellular senescence oxidative stress H2O2 hydrogen peroxide hair follicle dermal papilla cells DPC balding follicles androgen growth inhibition high-throughput screening assay hair follicle cells

TLDR Certain compounds can protect hair cells from aging and promote growth.

The study investigated the role of cellular senescence in age-related hair thinning, focusing on the impact of oxidative stress, particularly H2O2, on human hair follicle dermal papilla cells (DPC). It was found that DPC from balding follicles were more prone to senescence due to oxidative stress and androgen growth inhibition compared to non-balding follicles. A high-throughput screening assay was developed to test over 40 actives for their ability to stimulate DPC proliferation and protect against H2O2-induced senescence. The results identified three types of actives: those that stimulated proliferation without protecting against senescence, those that did both, and those that only protected against senescence without promoting proliferation.

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