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research A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

9 citations , March 2017 in “Journal of Visualized Experiments”

This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.

Pre-Clinical In-Vitro Assays for High Throughput Screening of Drug Candidates for Protection and Restoration of Immune Privilege in Alopecia Areata

research 1419 Pre-clinical in-vitro assays for high throughput screening of drug candidates for protection and restoration of immune privilege in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

This research developed new in vitro models for high-throughput screening of drugs that could protect or restore immune privilege in hair follicles, finding that Tofacitinib was effective in preventing inflammation-related marker upregulation, while Tacrolimus and αMSH worked specifically in outer root sheath keratinocytes.

research Development of 3-D Microbioreactor Systems for Cell-Based High Throughput Screening

1 citations , June 2012 in “OhioLink ETD Center (Ohio Library and Information Network)”

In this study, the 40-MBR system was shown to enhance drug-screening efficiency by providing reliable, real-time monitoring of cell conditions in 3-D cultures compared to traditional methods.

research Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay

111 citations , February 2017 in “Antiviral research”

In this study, researchers discovered that several compounds, including brequinar and 6-azauridine, exhibit significant anti-Zika virus activity using a high-throughput screen assay.

research 692 Prevention of H 2 O 2 -induced cellular senescence in human hair follicle dermal papilla cells

April 2017 in “Journal of Investigative Dermatology”

Certain compounds can protect hair cells from aging and promote growth.

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Community Join

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community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 2 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community Why not just take the drugs before hair loss?

in Chat 123 upvotes 6 months ago

Finasteride and dutasteride are discussed as preventative treatments for hair loss, with some advocating for early use and others concerned about side effects, especially before full maturity. Many regret not starting these treatments earlier due to their effectiveness in preventing or slowing hair loss.

community Oral Minoxidil and the "Facial Bloating" - what the research actually says

43 upvotes 4 months ago

Oral minoxidil can cause rare facial bloating, especially at higher doses and in women. Reducing sodium intake, drinking more water, and adjusting the dose can help manage side effects.

community Latest study on creatine and hair loss. 45 men, 3 months.

378 upvotes 1 year ago

Creatine does not significantly affect DHT levels or cause hair loss. Some users continue using finasteride and minoxidil while taking creatine, expressing skepticism about its impact on hair loss.

community dut doomers - any photo evidence of people regrowing AFTER going back to fin?

in Finasteride/Dutasteride 23 upvotes 10 months ago

Some users experience worsening hair loss with dutasteride and improvement after switching back to finasteride, while others find better results with dutasteride. The effectiveness of treatments like finasteride, dutasteride, minoxidil, and RU58841 varies, requiring individuals to try different combinations or dosages to find what works best.

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SMP Specialist
Craig Bottomley-High
Studham, England, United Kingdom
13+ yrs

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Craig Bottomley-High