Histidine Decarboxylase Expression Influences the Neofolliculogenesis of Newborn Mouse Dermal Cells

The study from 2012 examined the influence of histidine decarboxylase (HDC) on hair follicle development in newborn mice. It was found that HDC gene expression in dermal cells from C57BL/6 mice significantly decreased from the day of birth (p0) to seven days after birth (p7), which corresponded with a reduced capacity of these cells to induce hair follicles. By suppressing HDC expression in p0 dermal cells using small interfering RNA (siRNA) and then injecting these cells with adult epidermal cells into nude mice, it was observed that the treated dermal cells led to the formation of fewer and smaller hair follicle structures, as well as shorter and thinner hair shafts, compared to mock treated cells. This suggests that HDC plays a crucial role in the hair-inducing ability of dermal cells shortly after birth.