Aligned Membranes Regulate Wound Healing Via MMP12 Secreted By Macrophages

January 2025 in “ PLoS ONE ”

Hongli Ma, Limin Gong, Xi Yang, Hui Fang, Jiacai He, Chenbing Wang

MMP12 macrophages electrospinning membranes fibroblast migration scar formation hair follicle regeneration collagen deposition single-cell RNA sequencing phagocytosis immune responses wound healing skin repair biological dressings

Studysummary This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on journals.plos.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Integrated-Omics Profiling Unveils the Disparities of Host Defense to ECM Scaffolds During Wound Healing in Aged Individuals

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.

Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

research Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

6 citations , April 2022 in “Journal of diabetes research”

This study found that type II diabetes inhibited hair follicle regeneration and skin cell proliferation in mice, potentially explaining reduced skin renewal and chronic wound formation in diabetes.

research Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing

66 citations , May 2021 in “Science Advances”

In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.

research Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing

2 citations , August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that electrospun membranes with aligned surface topography enhanced wound healing and hair follicle regeneration while modulating the immune response in a mouse skin wound model.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations , March 2017 in “Nature Communications”

This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , January 2017 in “Science”

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

research Wound Healing and Skin Regeneration

359 citations , January 2015 in “Cold Spring Harbor Perspectives in Medicine”

This article reviews the role of skin appendages in wound healing and appendage regeneration, discussing cellular and molecular mechanisms but reports no new experimental findings.

research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers

33 citations , March 2013 in “Journal of Investigative Dermatology”

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”