research The Diameter Factor of Aligned Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization in an Immune Way
The study investigated the impact of fiber diameter in aligned electrospinning membranes on skin wound healing. Membranes with a diameter of 319±100 nm (A300) were found to significantly enhance cell proliferation, spreading, and skin wound healing, including epithelization, vascularization, and hair follicle regeneration. The molecular mechanism involved A300 promoting macrophage transformation to reparative phenotypes with increased expression of IL10 and TGFβ, which facilitated epidermal cell migration through the secretion of matrix metalloproteinases 12 (MMP12). These findings suggested that A300 membranes could be a promising candidate for guided skin regeneration applications.
