The study investigated the impact of fiber diameter in aligned electrospinning membranes on skin wound healing. Membranes with a diameter of 319±100 nm (A300) were found to significantly enhance cell proliferation, spreading, and skin wound healing, including epithelization, vascularization, and hair follicle regeneration. The molecular mechanism involved A300 promoting macrophage transformation to reparative phenotypes with increased expression of IL10 and TGFβ, which facilitated epidermal cell migration through the secretion of matrix metalloproteinases 12 (MMP12). These findings suggested that A300 membranes could be a promising candidate for guided skin regeneration applications.
66 citations
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May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
14 citations
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November 2020 in “International Journal of Biological Macromolecules” Mushroom-based scaffolds help heal skin wounds and regrow hair.
38 citations
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December 2019 in “Iranian Biomedical Journal” Hair follicle stem cells help burns heal faster and stronger.
1 citations
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February 2024 in “Journal of nanobiotechnology” Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.
8 citations
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May 2023 in “Gels” Chitosan hydrogels are promising for repairing blood vessels but need improvements in strength and compatibility.
April 2024 in “Molecules/Molecules online/Molecules annual” The composite sponge helps heal diabetic wounds by reducing inflammation and promoting new blood vessel growth.
October 2023 in “Biomaterials” Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.
1 citations
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January 2024 in “Theranostics” Exosomes show promise for future tissue regeneration.
