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Glossary Ion Channels

specialized proteins in cell membranes that regulate ion flow

Ion channels are specialized proteins embedded in cell membranes that allow ions (such as sodium, potassium, calcium, and chloride) to pass in and out of cells. These channels play a crucial role in various physiological processes, including nerve impulse transmission, muscle contraction, and maintaining the cell's electrical balance. They can open or close in response to specific signals, such as changes in voltage across the membrane or the binding of a chemical messenger.

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research TRPV3 Ion Channel: From Gene to Pharmacology

2 citations , May 2023 in “International Journal of Molecular Sciences”

This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.

research Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

29 citations , February 2021 in “Cancers”

This review discusses the role of ion channels in ovarian cancer progression and chemotherapy resistance, highlighting their potential as targets for diagnosis and treatment, but reports no new clinical results.

research Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

19 citations , December 2016 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

This study found that multiple ion channel modulators, used here at clinical concentrations, increased intracellular calcium release in prostate and breast cancer cell lines.

research Potassium channels: new targets for drug treatment.

1 citations , October 1996 in “PubMed”

This article highlights the role of potassium channels in cell membranes as targets for drug therapies addressing hypertension, hair loss, and diabetes, without reporting new research findings.

Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?

research Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?

January 2022 in “Function”

This article analyzes the potential for insights from monogenic disorders to inform the understanding and treatment of common polygenic diseases, though complete predictability based on genotype remains unrealistic.

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community GT20029 Will Replace Finasteride For Hair Loss

58 upvotes 3 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

community Have you ever seen a "back from the dead" result that DIDNT use microneedling?

in Microneedling 33 upvotes 1 year ago

Some users report significant hair regrowth without microneedling, using treatments like finasteride, minoxidil, and dutasteride. Others believe microneedling enhances results, but opinions vary on its necessity.

community Progress pictures. 2 months on Fin, 4 on Min.

in Progress Pictures 191 upvotes 1 year ago

The user experienced significant hair regrowth after using Finasteride for 2 months and Minoxidil for 4 months, along with a derma roller. They reported no side effects from the treatments and noted that Finasteride seemed to contribute most to the progress.

community Haircafe video on Min Sulfate, thoughts?

in Research/Science 101 upvotes 10 months ago

Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

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