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research 17β-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway

9 citations , August 2021 in “Biomedicines”

This study found that 17β-estradiol was the most powerful hormone for inducing APE1/Ref-1 secretion in cultured vascular endothelial cells, with secretion occurring through exosomes dependent on estrogen receptors and intracellular calcium.

research Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia‐inducible factor activation

7 citations , December 2020 in “Clinical and Experimental Dermatology”

This study found that cepharanthine and its structural analogues may stimulate hair growth by promoting the proliferation of human dermal papilla cells and increasing VEGF expression in vitro.

research In search of decoding the syntax of the bioelements in human hair – A critical overview

9 citations , April 2018 in “Journal of trace elements in medicine and biology”

This review presents the practice of using hair bioelement analysis to assess nutritional status or environmental exposure, proposing complex interactions and hypotheses regarding depression and autism but reports no new clinical results.

Mechanism of Action of Minoxidil Sulfate-Induced Vasodilation: A Role for Increased Potassium Permeability

research Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.

48 citations , June 1988 in “PubMed”

In this study, minoxidil sulfate was found to relax norepinephrine-induced contractions in rabbit mesenteric arteries, possibly by acting as a K+ channel agonist, but it did not relax K+-induced contractions.

LP-161 Tjalma Syndrome (Pseudo-Pseudo Meigs Syndrome): Polyserositis With Increased CA-125 in Patients With Systemic Lupus Erythematosus

research LP-161 Tjalma syndrome (Pseudo-Pseudo Meigs Syndrome): polyserositis with increased CA-125 in patients with systemic lupus erythematosus

July 2023

This case report highlights that Tjalma Syndrome may present as a main symptom of systemic lupus erythematosus and should be considered in patients with ascites, pleural effusions, and elevated CA-125 levels.

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community If you're worried that you're beginning to develop gyno on fin...

32 upvotes 3 months ago

Finasteride can cause gynecomastia due to increased estrogen from reduced DHT conversion, which some users manage by losing weight and taking supplements like DIM and calcium D-glucarate. Users discuss various experiences with finasteride, dutasteride, and minoxidil, noting side effects and strategies to mitigate them, including switching medications and considering surgery.

community is it fin shed? how to solve this. pls help

1 upvotes 8 months ago

An 18-year-old male using minoxidil and finasteride is experiencing increased hair loss, possibly due to a shedding phase from finasteride. He also takes zinc, magnesium, calcium, and vitamin C, and is concerned about hair loss from his temples.

community Guide To Finasteride and Avoiding Side Effects

in Finasteride/Dutasteride 26 upvotes 4 years ago

The conversation provides a guide on using finasteride for hair loss, suggesting to start with a quarter of a 1mg pill daily after ensuring estradiol levels are within a specific range, and potentially increasing the dose if no side effects occur. It also recommends supplements like DIM, Calcium d-glucarate, and Zinc to manage high estradiol levels and side effects from finasteride.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community Creatine, my hair loss, and my DHT levels. An anecdote with lab values.

165 upvotes 1 year ago

Increased hair loss after starting a 10g daily creatine regimen, possibly linked to elevated DHT levels despite dutasteride use. Stopping creatine reduced shedding, but the exact cause is uncertain, with discussions on exercise and lifestyle impacts.

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