Gene Variants Associated With Acne Vulgaris Presentation and Severity: A Systematic Review and Meta-Analysis

    April 2021 in “ BMC Medical Genomics ”
    Anna Hwee Sing Heng, Yee‐How Say, Yang Yie Sio, Yu Ting Ng, Fook Tim Chew
    TLDR Certain gene variants can influence acne risk and severity.
    This systematic review and meta-analysis investigated genetic factors associated with acne vulgaris presentation and severity, analyzing data from 982 acne cases and 846 controls. The study identified 60 genes and 100 variants linked to acne, focusing on genes related to inflammatory responses and sebaceous gland function. Notably, the TNF rs1800629 A allele and CYP17A1 rs743572 T allele were associated with reduced risks of mild and severe acne, respectively, while the FST rs629725 A allele was linked to a modestly increased risk. The study also identified 15 novel SNPs in the TLR4 gene associated with acne. These findings highlighted the potential of genetic variants in influencing acne risk and underscored the importance of understanding genetic susceptibility to develop effective treatments. However, significant heterogeneity and publication bias were noted, emphasizing the need for further research.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 878 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Why Breezula Won’t Work for Everyone.

      in Chat  28 upvotes 6 days ago
      Breezula, a new topical hair loss treatment, is expected to be expensive, with an estimated cost of €300 per month, making it less accessible compared to cheaper alternatives like finasteride. Some users discuss the potential for cheaper generics from countries like China and India, while others debate the effectiveness and pricing strategy of Breezula compared to other treatments like minoxidil and RU58841.

      community EMA is re-examining Winlevi (clascoterone at lower concentration)

      in Treatment  8 upvotes 6 months ago
      Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

    Similar Research

    5 / 1000+ results