Gene Variants Associated With Acne Vulgaris Presentation and Severity: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis identified genetic variants associated with acne vulgaris presentation and severity, focusing on genes related to inflammatory responses and sebaceous gland function. The study analyzed data from 982 acne cases and 846 controls, revealing that TNF rs1800629 A allele and CYP17A1 rs743572 T allele carriers had a reduced risk of mild and severe acne, respectively. Conversely, the FST rs629725 A allele was associated with a modestly increased risk of acne. The research highlighted the potential of these genetic factors in understanding acne pathogenesis and developing effective treatments.