CAG Polymorphism in the Androgen Receptor Gene in Women May Be Associated with Nodulocystic Acne

The study conducted on a Turkish population aimed to explore the link between CAG repeat polymorphism in the androgen receptor gene (ARG) and the occurrence of nodulocystic acne. It included 199 subjects, with 100 severe acne patients (51 males and 49 females) and 99 controls (49 males and 50 females). The results showed a significant difference in the mean allele length between female patients and the control group, with a mean of 19.34 in patients and 19.7 in controls, indicating that a lower number of CAG repeats in the ARG might be associated with the development of acne in females without hirsutism (p = 0.0059). However, no significant association was found in male subjects. The study suggests that the CAG trinucleotide repeat count in the ARG could be linked to acne in women without hirsutism, but this is not the case for men, and calls for further research with larger and more varied populations to confirm these findings.