The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

Different types of skin cells play specific roles in development, healing, and cancer.

Stem cells and their surrounding environment in hair follicles work closely together, affecting hair growth and having implications for cancer and tissue regeneration.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Different body areas in mice produce different hair types due to interactions between skin layers.

Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.

Hair follicle biology advancements may lead to better hair growth disorder treatments.