The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function

August 2021 in “ EMBO Reports ”

Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens M. Seeger, Hamid Kashkar, Catherin Niemann

Bcl-2 protein hair follicle stem cells hair loss stem cell quiescence stem cell activation hair growth

Studysummary This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.

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The study "The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function" found that the Bcl-2 protein is crucial for the maintenance and function of hair follicle stem cells. Lack of Bcl-2 led to a decrease in these stem cells, causing hair loss. Bcl-2 also regulates the balance between hair follicle stem cell quiescence and activation, which is essential for normal hair growth. The study suggests that Bcl-2 could be a potential target for treating hair loss conditions.

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research The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function

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This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.

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research Stem Cell Dynamics in the Hair Follicle Niche

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91 citations , June 2011 in “The EMBO Journal”

This study demonstrates that hair follicle bulge stem cells can transition into other stem cell compartments, indicating their role in maintaining both hair follicles and sebaceous glands.

research Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development

81 citations , September 2009 in “Birth defects research”

This review discusses the mechanisms behind hair patterning during mouse embryonic development and reports no new experimental findings.

research Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells

415 citations , January 2008 in “Cell”

NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

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research Hair Follicle Stem Cells: Insights from the 2003 Workshop

142 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

555 citations , July 2001 in “Genes & Development”

This study found that Tcf3 and Lef1 differently regulate cell differentiation in multipotent skin stem cells, with Tcf3 promoting follicle-like features and Lef1, when modified, promoting sebocyte differentiation.

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research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

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