TLDR The gene Prss53 affects hair shape and bone development in rabbits.
The study confirmed a direct link between the gene Prss53 and hair curvature, as well as skeletal dysplasia, by using CRISPR/Cas9 to generate Prss53-mutated rabbits. Homozygous Prss53-/- rabbits displayed curved hair and severe skeletal malformations, while heterozygous Prss53+/- rabbits did not show these abnormalities. The curved hair was associated with denser and less defined cuticular septation and incomplete hair follicle compartments, alongside decreased expression of keratinocyte differentiation genes. Additionally, Prss53-/- rabbits had increased mortality rates, reduced plasma calcium, and lower serum alkaline phosphatase levels, suggesting that disrupted calcium metabolism may contribute to the observed hair and skeletal phenotypes. This research provided the first animal evidence of Prss53's role in hair shape and highlighted its importance in calcium metabolism.
Cited in this study
4 / 4 results
7 citations
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December 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
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March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.
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April 2013 in “Development” More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
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November 2013 in “Trends in pharmacological sciences” Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.
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January 2009 in “Experimental Dermatology” The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
