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    Did you mean Keratinocyte Differentiation?
    Glossary Keratinocyte Differentiation

    process where skin cells mature and produce protective keratin

    Keratinocyte differentiation, also known as keratinocyte maturation, is the process by which keratinocytes, the primary cells in the outer layer of the skin, develop and change as they move from the deeper layers to the surface. During this journey, they produce keratin, a protective protein, and eventually form the tough, outermost layer of the skin that acts as a barrier against environmental damage. This process is crucial for maintaining skin integrity and function.

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    1. Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene <i>ID2</i>, by contact sensitizers in human bulge‐derived keratinocytes Journal of Biochemical and Molecular Toxicology · 2010 · 6 citations
    2. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    3. 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth 2023
    4. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    5. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    6. 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation 2021
    7. 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression 2020
    8. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation 2010 · 68 citations
    9. The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin PLoS ONE · 2025
    10. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
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