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GlossaryJNK pathway (JNK signaling pathway)

signaling cascade responding to stress, regulating inflammation and cell death

The JNK pathway, also known as the c-Jun N-terminal kinase pathway, is a signaling cascade within cells that responds to stress stimuli, such as UV radiation and inflammatory cytokines. It plays a crucial role in regulating various cellular processes, including inflammation, apoptosis (programmed cell death), and cell differentiation. This pathway is significant in understanding diseases like cancer and neurodegenerative disorders, as well as conditions affecting hair growth and alopecia.

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research sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

9 citations, June 2016 in “Stem cells”

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

research Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

13 citations, September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

research Physiological Functions of PP2A: Lessons from Genetically Modified Mice

87 citations, July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK-ERK Signaling Pathway

45 citations, April 2013 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

research Activin B Promotes Epithelial Wound Healing In Vivo Through RhoA-JNK Signaling Pathway

38 citations, September 2011 in “PLOS ONE”

Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.

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community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 5 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 6 upvotes 6 months ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.