Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans

    September 2006 in “ American Journal Of Pathology ”
    Marina Grachtchouk, Jianhong Liu, Aiqin Wang … Andrzej A. Dlugosz
    Studysummary In this study, researchers found that overexpression of the Hedgehog signaling effector Gli2 in mice led to odontogenic keratocysts development, implicating GLI transcription factors in human keratocyst pathogenesis.
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    Research cited in this study 7

    1. GLI2 Is Expressed in Normal Human Epidermis and Basal Cell Carcinoma and Induces GLI1 Expression by Binding to Its Promoter Journal of Investigative Dermatology · 2004
    2. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    3. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    4. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    5. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    6. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    7. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997