Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans

    September 2006 in “ American Journal Of Pathology ”
    Marina Grachtchouk, Jianhong Liu, Aiqin Wang, Lebing Wei, Christopher K. Bichakjian, William P. Meehan, Augusto F. G. Paulino, Thomas J. Giordano, Andrzej A. Dlugosz
    TLDR Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.
    The study concluded that odontogenic keratocysts (OKCs) originated from quiescent epithelial rests and were linked to deregulated Hedgehog signaling in both mice and humans. This deregulation was significant in the development and behavior of OKCs, suggesting a neoplastic nature rather than a simple cystic lesion. The research highlighted the importance of the Hedgehog pathway in the pathogenesis of these cysts, providing insights into potential therapeutic targets for treatment.
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