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    Glossary Desert Hedgehog

    gene involved in hair follicle development and cell differentiation

    Desert Hedgehog (DHH) is a gene that encodes a signaling protein involved in the development of various tissues, including hair follicles. It plays a crucial role in the regulation of cell growth and differentiation, particularly in the formation of the dermal papilla, which is essential for hair follicle development and cycling. Mutations or disruptions in the DHH gene can lead to hair growth disorders and contribute to conditions like alopecia.

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    Research 30 of 268

    1. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    2. The effects of sonic, desert and Indian hedgehog signalling in skin 2003
    3. Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2005 · 113 citations
    4. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    5. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    6. Abstract CN06-04: The hedgehog signaling pathway in cancer. Molecular Cancer Therapeutics · 2011
    7. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    8. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    9. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020 · 77 citations
    10. Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms ˜The œAmerican journal of pathology · 2011 · 68 citations
    11. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    12. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    13. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    14. DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptch flox/flox CD4Cre +/− Mice Journal of Investigative Dermatology · 2014 · 11 citations
    15. Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma Journal of Oncology · 2022 · 5 citations
    16. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    17. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy Cancers · 2021 · 11 citations
    18. Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors International Journal of Molecular Sciences · 2026
    19. IGFBP5 Promotes Neuronal Apoptosis in a 6-OHDA-Toxicant Model of Parkinson’s Disease by Inhibiting the Sonic Hedgehog Signaling Pathway Medical Principles and Practice · 2024 · 8 citations
    20. Hairy tale of signaling in hair follicle development and cycling Seminars in cell & developmental biology · 2012 · 161 citations
    21. Shh Gene Regulates the Proliferation and Apoptosis of Dermal Papilla Cells to Affect Its Differential Expression in Secondary Hair Follicle Growth Cycle of Cashmere Goats Animals · 2024 · 7 citations
    22. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    23. Ptch2 is a Potential Regulator of Mesenchymal Stem Cells Frontiers in Physiology · 2022 · 3 citations
    24. Targeting of Smoothened for therapeutic gain Trends in Pharmacological Sciences · 2014 · 105 citations
    25. Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma Cancer Prevention Research · 2010 · 21 citations
    26. Cutaneous wound healing: recruiting developmental pathways for regeneration Cellular and Molecular Life Sciences · 2012 · 471 citations
    27. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle 2021 · 4 citations
    28. Regulation of stem cell fate by HSPGs: implication in hair follicle cycling npj Regenerative Medicine · 2022 · 3 citations
    29. Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression Cancer Research · 2006 · 176 citations
    30. Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways Preprints.org · 2025