The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis

    October 1999 in “ Differentiation ”
    Joseph A. Rothnagel, Toshihiko Seki, Masashi Ogo … Dennis R. Roop
    Studysummary This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.
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    Research cited in this study 12

    1. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    2. The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs Genomics · 1998
    3. Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice DNA and Cell Biology · 1998
    4. Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice Journal of Biological Chemistry · 1997
    5. Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita Nature Genetics · 1995
    6. A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice Proceedings of the National Academy of Sciences · 1995
    7. Hair Follicle Companion Layer: Reacquainting an Old Friend ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1995
    8. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum) Differentiation · 1988
    9. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    10. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    11. Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    12. Expression of Epidermal Keratins and Filaggrin During Human Fetal Skin Development The Journal of Cell Biology · 1985

    Related research 2

    1. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    2. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989