Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice

    February 1998 in “ DNA and Cell Biology ”
    Ángel Ramı́rez, MIGUEL VIDAL, Ana Bravo, José L. Jorcano
    Studysummary This research identified that the constitutive and inducible expression of the Keratin 6 gene in transgenic mice skin is controlled by multiple regulatory elements spread throughout its 5' flanking region.
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    Research cited in this study 4

    1. Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita Nature Genetics · 1995
    2. A 5'-Upstream Region of a Bovine Keratin 6 Gene Confers Tissue-Specific Expression and Hyperproliferation-Related Induction in Transgenic Mice Proceedings of the National Academy of Sciences · 1995
    3. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993
    4. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987

    Related research 1

    1. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989