Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice
February 1998
in “
DNA and Cell Biology
”
TLDR K6 gene expression can be controlled and manipulated in mice for studying skin disorders.
The study focused on the keratin 6 (K6) gene, which is expressed in hair follicles and stratified epithelia, and is induced in hyperproliferative conditions. Researchers analyzed a 9 kbp region of the K6 gene in transgenic mice to identify sequences controlling its expression. They found that K6 expression requires cooperation between distal and proximal elements, with inducible expression under hyperproliferative conditions linked to a 2.4 kbp fragment before the transcription start site. This complex regulatory organization allows for targeted gene expression in transgenic mouse skin, which could be useful for studying epidermal hyperproliferative disorders.
