TLDR Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.
The study used Krt6a-Cre transgenic mice to achieve LoxP-mediated recombination in the companion cell layer of the hair follicle and, when induced by retinoic acid, in the interfollicular epidermis. The Krt6a promoter facilitated targeted gene inactivation in these cell populations, providing a method to study gene effects on hair follicle development, particularly in signaling pathways like hedgehog and Wnt. The inducible promoter allowed for differentiation of gene function between follicle cells and interfollicular epidermis, offering insights into tumor suppressor genes and hair follicle development.
101 citations
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August 2001 in “The Journal of Cell Biology” A new keratin 6 type in mice explains why some mice without certain keratin genes still have normal hair and nails.
45 citations
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March 2001 in “Journal of Investigative Dermatology” A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.
75 citations
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October 1999 in “Differentiation” Mouse keratin 6 isoforms have different expression patterns in various tissues.
139 citations
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December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” K6hf is a unique protein found only in a specific layer of hair follicles.
79 citations
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October 1998 in “Genomics” Mouse keratin 6 genes evolved independently from human ones and are regulated differently.
55 citations
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May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology”
38 citations
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December 2006 in “Journal of Investigative Dermatology” Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
176 citations
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February 2006 in “Cancer Research” Patched1 helps prevent tumors by controlling cell growth.
52 citations
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October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
55 citations
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September 2014 in “Development” Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.
96 citations
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June 2017 in “Nature Communications” A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.
