Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in This Gene Family for Its Expression in the Adult Mouse Tail and Ear
May 2000
in “
Endocrinology
”
TLDR A new gene, mrp4, is found in mice and may play a unique role in hair follicle development in tails and ears.
The document reports the identification and characterization of a new mitogen-regulated protein/proliferin gene, mrp4, which is 91% identical in amino acid sequence to other MRP/PLF proteins but lacks two glycosylation sites, resulting in a lower molecular weight. Mrp4 is expressed in the placenta, peaking on day 12, and uniquely in the adult mouse skin, specifically in the hair follicles of the ears and tails. This suggests that MRP/PLFs may have roles beyond pregnancy-related growth and angiogenesis, with MRP4 potentially playing a distinct role in the growth and development of hair follicles in these areas.
