Mitogen-Regulated Protein/Proliferin mRNA Induction Following Single Applications of Tumor Promoters to Murine Skin

May 2005 in “ Molecular Carcinogenesis ”

Craig L.J. Parfett

mitogen-regulated protein proliferin mRNA tumor promoters 12-O-tetradecanoylphorbol-13-acetate TPA benzoyl peroxide BPO SENCAR mice ornithine decarboxylase junB reverse transcriptase-polymerase chain reactions MRP plf1 mrp3 Northern blot hybridizations

Studysummary This study found that mrp/plf-mRNA expression in murine skin increases in response to different tumor promoters, suggesting its potential as a short-term biomarker for chemical carcinogenesis.

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The study investigated the response of mitogen-regulated protein/proliferin (mrp/plf) mRNA to tumor promoters in murine skin. Researchers applied tumor promoters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and benzoyl peroxide (BPO), to the skin of SENCAR mice and analyzed RNA samples from treated areas. They found that mrp/plf-mRNA was not detected in Northern blot hybridizations, but significant increases in mRNAs for genes like ornithine decarboxylase and junB were observed in response to TPA. Reverse transcriptase-polymerase chain reactions revealed fully-processed MRP/plf-mRNA in most TPA-treated and some BPO-treated animals, with predominant expression of plf1 and mrp3. The study concluded that mrp/plf-mRNA was differentially expressed in response to tumor promoters and could serve as a biomarker for tumor-promoting effects in chemical carcinogenesis.

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research Mrp3, A Mitogen-Regulated Protein/Proliferin Gene Expressed In Wound Healing And In Hair Follicles

19 citations , May 2001 in “Endocrinology”

This study suggests that Mrp3 may play a role in both wound healing and the hair follicle cycle as a growth factor and/or angiogenesis factor.

research Mrp3, A Mitogen-Regulated Protein/Proliferin Gene Expressed In Wound Healing And In Hair Follicles

34 citations , May 2001 in “Endocrinology”

This study found that MRP3 is induced in wound edge keratinocytes during wound healing and may play a role as a growth or angiogenesis factor in this process and the hair follicle cycle.

research Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in This Gene Family for Its Expression in the Adult Mouse Tail and Ear

16 citations , May 2000 in “Endocrinology”

This study identified a new gene, mrp4, in mice, which suggests it may have a unique role in the growth and development of hair follicles in the ears and tails.