Mrp3, A Mitogen-Regulated Protein/Proliferin Gene Expressed In Wound Healing And In Hair Follicles

The study demonstrated that Mrp3, a mitogen-regulated protein, was induced in keratinocytes at the wound edge during cutaneous wound healing and appeared in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. In cultured keratinocytes, Mrp3 was induced by keratinocyte growth factor but not by epidermal growth factor or transforming growth factor type α. Transgenic mice showed wound- and hair cycle-induced expression of a lacZ transgene under the control of Mrp3 regulatory sequences. These findings suggested that Mrp3 might play a role as a growth factor and/or angiogenesis factor in wound healing and the hair follicle cycle.