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GlossaryGene Transcription (RNA synthesis)

process where DNA is converted into RNA

Gene transcription, also known simply as transcription, is the process by which a cell converts a segment of DNA into RNA. This is a crucial step in gene expression, where the information encoded in a gene is used to produce a functional product, typically a protein. During transcription, an enzyme called RNA polymerase reads the DNA sequence of a gene and synthesizes a complementary RNA strand, which can then be translated into a protein or serve other functions within the cell.

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May 2007 in “Proceedings of the National Academy of Sciences of the United States of America”

Alexander the Great's engineers built a causeway using a natural sand bridge, some tiger moths avoid bats by mimicking toxic relatives' sounds, early metabolism and RNA enzymes support the ancient RNA world theory, and vitamin D is crucial for hair growth and its absence can cause baldness.

research Genetic Regulation of the Androgen Receptor: A Study of Testicular Feminization in the Mouse

20 citations, March 1975 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

The study concludes that a genetic mutation in TFM mice leads to reduced androgen receptor activity, affecting the body's response to male hormones.

research Glucose and Acetate Metabolism by Isolated Sheep Wool Follicles

8 citations, April 1965 in “Archives of biochemistry and biophysics”

Sheep wool follicles can metabolize both glucose and acetate using different pathways important for wool growth.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations, January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

research ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes

4 citations, May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

ELL is crucial for gene transcription related to skin cell growth.

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community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Does CosmeRNA target the root cause of MPB?

in Chat 1 year ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 1 week ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Kintor Pharma Announces Successful Completion of Phase II Clinical Trial of KX-826 for Treatment of Androgenetic Alopecia in the US

in Research/Science 122 upvotes 1 year ago

Kintor Pharma announced successful Phase II trial results for KX-826 in treating hair loss, showing it's comparable to finasteride and can be used with it. Some participants saw a 10 hair/cm^2 increase, which is considered a good outcome at the low dose used.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 5 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

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