Genetic Regulation of the Androgen Receptor: A Study of Testicular Feminization in the Mouse

March 1975 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”

C. Wayne Bardin, Leslie P. Bullock, Olli A. Jänne, Samson T. Jacob

androgen receptor testicular feminization androgens testosterone dihydrotestosterone RNA synthesis DNA synthesis androgen-dependent differentiation AR TFM DHT

TLDR The study concludes that a genetic mutation in TFM mice leads to reduced androgen receptor activity, affecting the body's response to male hormones.

The study on testicular feminization (TFM) in mice, published in 1975, investigated the genetic regulation of the androgen receptor. TFM is an inherited disorder causing genetic males to present as phenotypic females due to end organ insensitivity to androgens. The research indicated that a major tissue abnormality in TFM is decreased cytosol androgen receptor activity, leading to reduced nuclear binding of testosterone and dihydrotestosterone. This deficiency likely impairs RNA and DNA synthesis initiation, explaining the androgen insensitivity. The findings supported a direct correlation between the TFM gene, androgen receptor activity, and androgen response.

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research Anabolic Effect of Dihydrotestosterone in Testicular Feminization Syndrome

2 citations, September 1971 in “Metabolism, clinical and experimental”

Dihydrotestosterone has a reduced effect on muscle-building in people with testicular feminization syndrome, especially after their gonads are removed.