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Glossary mRNA sequencing

technique to determine the sequence of messenger RNA molecules

mRNA sequencing, also known as mRNA-seq, is a technique used to determine the sequence of messenger RNA (mRNA) molecules in a sample. This method helps researchers understand which genes are being actively expressed in a cell or tissue at a given time, providing insights into cellular functions and disease mechanisms.

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research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

In this study, researchers found that the SLICK1 allele in cattle may alter local immune regulation, hair growth, and tissue remodeling, as indicated by differential gene expression pathways associated with immune and inflammatory responses in slick vs. nonslick Holsteins.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

In this study, researchers analyzed miRNA and gene expression in the hair follicles of FMD during different hair cycle stages, identifying differential expression patterns and key pathways involved in hair follicle development and growth.

research Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak

December 2022 in “Cells”

This study found significant differences in mRNA and miRNA expression between yak dermal papilla cells and epidermal hair matrix cells, suggesting important roles for these molecules in hair follicle development.

research High-throughput sequencing of hair follicle development-related micrornas in cashmere goat at various fetal periods

33 citations , December 2017 in “Saudi Journal of Biological Sciences”

In this study, researchers found that microRNAs in the oar-let-7 and oar-miR-200 families were significantly up-regulated during critical fetal periods of cashmere goat hair follicle development, suggesting their role in this process.

research Application of lncRNA-miRNA-mRNA ceRNA network analysis in the treatment of androgenic alopecia.

1 citations , December 2022 in “PubMed”

This study identified a long noncoding RNA, LOXL1-AS1, with potential diagnostic significance in androgenic alopecia, which may regulate TP53 expression by targeting hsa-miR-5193 within a ceRNA network.

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community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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