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Glossary Candidate Genes

specific genes believed to influence a particular trait or disease

Candidate genes are specific genes that researchers believe may be associated with a particular trait or disease, based on their known biological functions or previous studies. For example, in the context of alopecia (hair loss), scientists might identify candidate genes that are involved in hair growth or immune system regulation, as these processes are relevant to the condition. Identifying and studying these genes can help in understanding the underlying mechanisms of the disease and potentially lead to targeted treatments.

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Research

5 / 1000+ results

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

research Candidate genes of SARS-CoV-2 gender susceptibility

27 citations , November 2021 in “Scientific Reports”

This study used bioinformatics to explore molecular differences in testicular and ovarian responses to SARS-CoV-2, identifying genes that could be associated with sex differences in infection outcomes.

research Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study

6 citations , November 2019 in “The application of clinical genetics”

This study identified a significant genetic association between the TNFα gene and alopecia areata susceptibility in the Jordanian Arab population.

research Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes

3 citations , February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY”

This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.

Candidate SNP Markers of Reproductive Potential Predicted by Significant Change in Affinity of TATA-Binding Protein for Human Gene Promoters

research Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters

16 citations , February 2018 in “BMC Genomics”

This paper reviews genome-based personalized medicine developments using Web services for analyzing SNPs in reproductive potential but reports no new clinical findings.

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Community Join

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community Does someone like Prince William have such intense balding genetics that not even Dutasteride can save them?

in Chat 113 upvotes 1 year ago

Some men have strong balding genetics that treatments like Dutasteride, Minoxidil, or Finasteride may not fully address. Early intervention is believed to help, but many accept hair loss without treatment.

community Will I be a good candidate for Finasteride?

5 years ago

A 17-year-old is considering finasteride for hair loss but is advised to wait due to potential hormonal effects at a young age. Alternatives like minoxidil, micro-needling, vitamins, and lifestyle changes are suggested instead.

community Will I be a good candidate for finasteride?

1 upvotes 5 years ago

A 17-year-old is considering finasteride for a receding hairline and seeks advice. Suggestions include starting with low-dose finasteride, trying dermarolling and Minoxidil, and consulting a physician.

community Why is the general consensus that if you can’t tolerate 5AR Inhibitors you’re “cooked”?

in Research/Science 15 upvotes 11 months ago

Alternatives to finasteride for hair loss include minoxidil, alfatrodial, fluridil, pyrilutamide, and Nizoral. These treatments may not be as effective as finasteride but can help slow hair loss progression.

community Does having low estrogen make one a better candidate for finasteride?

7 months ago

Low estrogen levels may reduce the risk of side effects from finasteride, such as gynecomastia. Some users plan to start with microneedling and minoxidil before trying finasteride, while others have experienced temporary side effects from topical finasteride but continued use without persistent issues.

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Learn

6 / 801 results

learn Hair Transplant

Are hair transplants in Turkey good? Hair transplants in Turkey are generally considered good and cost-effective, but quality varies by clinic.
Who is suitable for DHI hair transplant? Clinics say DHI suits men and women with several types of hair loss, but they also say suitability depends on donor supply, scalp condition and general health, and only a personal medical assessment can decide it.
Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.
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learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

learn Fluridil

a topical anti-androgen with less systemic involvement

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Scalp Micropigmentation

scalp tattoos to mimic the appearance of light stubble

Who is a good candidate for scalp micropigmentation? Good candidates for scalp micropigmentation include anyone experiencing hair loss or thinning.

learn Overview

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Experts

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21
Hair System Specialist
Jane Genesi
Marlton, PA, United States

Clinics

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Jane Genesi