Substrate Specific Sulfatase Activity from Hair Follicles in Recessive X-Linked Ichthyosis

The study investigated sulfatase activity in hair follicles of individuals with recessive X-linked ichthyosis, a genetic skin disorder. Researchers found that the enzyme activity was substrate-specific, meaning it varied depending on the type of substrate present. This specificity was significant in understanding the biochemical basis of the disorder, as it suggested that the deficiency in sulfatase activity could be linked to the accumulation of certain substrates, contributing to the skin symptoms observed in affected individuals. The findings provided insights into the enzymatic processes in hair follicles, which could have implications for understanding and potentially treating the condition.