Harnessing Microbiome, Bacterial Extracellular Vesicle, and Artificial Intelligence for Polycystic Ovary Syndrome Diagnosis and Management

    June 2025 in “ Biomolecules ”
    Bhawna Kushawaha, Tial T. Rem, Emanuele Pelosi
    Studysummary This review highlights that gut dysbiosis and bacterial extracellular vesicles are key factors in PCOS pathophysiology, and suggests AI-driven analysis of these profiles could enhance diagnostic accuracy and treatment personalization, though ethical concerns like data privacy and bias must be considered.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Optimized Polycystic Ovarian Disease Prognosis and Classification Using AI-Based Computational Approaches on Multi-Modality Data BMC Medical Informatics and Decision Making · 2024
    2. Reconsidering PCOS Etiology, Diagnosis, Clinical Subgroups, and Subgroup-Specific Treatments Endocrine and metabolic science · 2024
    3. Hyperandrogenism and Menstrual Imbalance Are the Best Predictors of Metformin Response in PCOS Patients Reproductive Biology and Endocrinology · 2022
    4. Comparative Analysis of Machine Learning Algorithms in Diagnosis of Polycystic Ovarian Syndrome International journal of computer applications · 2020
    5. The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Human Reproduction · 2016
    6. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    7. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 Endocrine Practice · 2015
    8. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
    9. Visually Scoring Hirsutism Human reproduction update · 2009
    10. The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report Fertility and Sterility · 2008
    11. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003