Polycystic Ovary Syndrome in Adolescents

June 2016 in “ Endocrinology and Metabolism Clinics of North America ”

Selma F. Witchel, Hailey Roumimper, Sharon E. Oberfield

Polycystic Ovary Syndrome PCOS hyperandrogenism irregular menses androgen assays hormonal therapy estrogen-containing compounds metformin estrogen therapy

TLDR The document concludes that diagnosing PCOS in teenagers is difficult and should focus on specific hormone levels and menstrual irregularities, while also considering treatment for symptoms and related health issues.

The document from June 1, 2016, addresses the complexity of diagnosing Polycystic Ovary Syndrome (PCOS) in adolescents, emphasizing that many PCOS symptoms can be mistaken for normal puberty changes. It suggests strict diagnostic criteria, focusing on hyperandrogenism and irregular menses postmenarche, while excluding polycystic ovary morphology and insulin resistance as criteria. The document notes the genetic factors identified by GWAS and the importance of specific androgen assays for diagnosing hyperandrogenism. It also discusses the challenges of using PCOM and AMH levels for diagnosis in adolescents, the need to rule out other conditions, and the treatment goals for adolescents with PCOS, including managing symptoms and comorbidities. Hormonal therapy with estrogen-containing compounds and metformin are mentioned as treatment options, with a call for more research on PCOS in multiethnic cohorts.

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research Diagnosis and Challenges of Polycystic Ovary Syndrome in Adolescence

30 citations , April 2014 in “Seminars in Reproductive Medicine”

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

research Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

1265 citations , December 2013 in “The Journal of Clinical Endocrinology and Metabolism”

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

research Prevalence of Hyperandrogenic States in Late Adolescent and Young Women: Epidemiological Survey on Italian High-School Students

34 citations , April 2013 in “The Journal of Clinical Endocrinology and Metabolism”

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.

research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

1514 citations , January 2012 in “Fertility and sterility”

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

research A Rational Approach to the Diagnosis of Polycystic Ovarian Syndrome During Adolescence

26 citations , November 2011 in “Arquivos Brasileiros De Endocrinologia E Metabologia”

Diagnosing PCOS in teenagers should focus on signs of excess male hormones and not rely solely on ovarian ultrasound or irregular periods, and should be reassessed in adulthood.

research The Diagnosis of Polycystic Ovary Syndrome in Adolescents

212 citations , September 2010 in “American Journal of Obstetrics and Gynecology”

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

research Visually Scoring Hirsutism

288 citations , June 2009 in “Human reproduction update”

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , November 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

research Treatment of the Adolescent Patient with Polycystic Ovary Syndrome

26 citations , June 2003 in “Obstetrics and gynecology clinics of North America”

More research is needed to understand the long-term benefits of insulin-sensitizing drugs for treating adolescents with PCOS.

research Screening for 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia Among Hyperandrogenic Women: A Prospective Study

216 citations , November 1999 in “Fertility and Sterility”

Testing basal 17-HP levels is a good way to screen for nonclassic adrenal hyperplasia in women with high androgen levels.