Intercellular Junctions in Normal Epidermis

The document reviewed the critical role of desmosomal cadherins, such as desmocollin and desmoglein, and plaque components like plakoglobin and plakophilin in maintaining epidermal structure and function. These proteins were essential for epithelial morphogenesis, cell positioning, and differentiation, with their misexpression or absence leading to conditions like Darier's disease and pemphigus vulgaris. The research emphasized their importance in desmosome assembly, stability, and the regulation of cell adhesion and migration, highlighting their complex interactions in preserving epidermal integrity and responding to cellular signals.