New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

    October 2024 in “ AAPS PharmSciTech ”
    Shahinaze A. Fouad, Taher A. Badr, Ahmed Abdelbary … Mohamed A. El-Nabarawi
    Studysummary This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.
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    Research cited in this study 10

    1. Combinatorial Therapy of Letrozole and Quercetin Loaded Spanlastics for Enhanced Cytotoxicity Against MCF-7 Breast Cancer Cells Pharmaceutics · 2022
    2. Skin Targeting of an Optimized Caffeine Nanostructured Lipid Carrier with Improved Efficiency Against Chemotherapy-Induced Alopecia International Journal of Applied Pharmaceutics · 2022
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    6. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012
    7. Effects of Caffeine and Siloxanetriol Alginate Caffeine as Anticellulite Agents on Fatty Tissue: Histological Evaluation Journal of cosmetic dermatology · 2008
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    9. Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation Skin Pharmacology and Physiology · 2007
    10. RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia PubMed · 2005