New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

October 2024 in “ AAPS PharmSciTech ”

Shahinaze A. Fouad, Taher A. Badr, Ahmed Abdelbary, Maha Fadel, Rehab Abdelmonem, Bhaskara Jasti, Mohamed A. El-Nabarawi

caffeine solid lipid nanoparticles CA-SLNs hydrogel subcutaneous fat tissue skin appendages SLNs gel

Studysummary This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.

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research Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies

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research Effects of Caffeine and Siloxanetriol Alginate Caffeine as Anticellulite Agents on Fatty Tissue: Histological Evaluation

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The Role of Hair Follicles in the Percutaneous Absorption of Caffeine