New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

October 2024 in “ AAPS PharmSciTech ”

Shahinaze A. Fouad, Taher A. Badr, Ahmed Abdelbary, Maha Fadel, Rehab Abdelmonem, Bhaskara Jasti, Mohamed A. El-Nabarawi

caffeine solid lipid nanoparticles CA-SLNs hydrogel subcutaneous fat tissue skin appendages SLNs gel

TLDR CA-SLN-Ngel significantly reduces cellulite more effectively than regular caffeine gel.

This study explores the use of caffeine-loaded solid lipid nanoparticles (CA-SLNs) for effective cellulite treatment. By optimizing formulation variables, the researchers developed CA-SLN-4, which demonstrated high entrapment efficiency, minimized particle size, and superior caffeine release. When incorporated into a hydrogel (CA-SLN-Ngel), it showed significant reduction in subcutaneous fat tissue thickness in rats, with reductions of 4.66 and 4.16 fold at 7 and 21 days, respectively, compared to a caffeine gel. The study highlights the potential of CA-SLN-Ngel as a promising topical treatment for cellulite, emphasizing the role of skin appendages in enhancing caffeine delivery.

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