Topical And Transdermal Lipid-Polymer Hybrid Nanoparticles: An Integration In Advancing Dermatological Treatments

August 2025 in “ Drug Delivery and Translational Research ”

Kok-Hou Lok, Hooi Leong Loo, Lay‐Hong Chuah

lipid-polymer hybrid nanoparticles LPN drug delivery biocompatibility controlled release hot-melt emulsification dermatological treatments wounds skin infections dermatitis psoriasis skin cancer pain management cosmetics

TLDR Lipid-polymer hybrid nanoparticles show promise for skin treatments but need better formulation strategies.

Lipid-polymer hybrid nanoparticles (LPN) combine the benefits of lipid and polymeric carriers to enhance drug delivery by improving biocompatibility, drug loading, stability, and controlled release. This review discusses the evolution of LPN structures and preparation methods, highlighting recent advancements like hot-melt emulsification for scalability. Despite their potential, the practical application of LPN in dermatological treatments, including wounds, skin infections, dermatitis, psoriasis, skin cancer, pain management, and cosmetics, remains uncertain. The review suggests revising formulation strategies to incorporate new methods for dermatological use.

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