Anti-Hair Loss Effect of a Shampoo Containing Caffeine and Adenosine

May 2024 in “ Journal of cosmetic dermatology ”

Dongxiao Chen, F P Yu, Congcong Wang, Haowei Chen, Jie Tan, Qingying Shi, Xiaoliang He, Xinyan Liu, Jing Liu, Huabing Zhao

caffeine adenosine phosphodiesterases cAMP cell metabolism proliferation hair growth phase hair shaft thickening

TLDR A shampoo with caffeine and adenosine may help prevent hair loss and thicken hair.

The study on 84 participants (77 completed) over 3 months found that a shampoo containing 0.4% caffeine and 0.2% adenosine significantly increased hair density from 118.25 hairs/cm² to 130.03 hairs/cm² and reduced hair loss episodes from 27.19 to 17.53 in the experimental group, with no significant changes in the control group. Participants reported high satisfaction with hair regrowth and renewal, though some experienced dryness. No adverse skin reactions were noted, supporting the shampoo's efficacy in reducing hair loss and enhancing hair density.

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